Phosphine- and Phosphine Oxide-Initiated Reaction Sequences
Dr Toy, Patrick Henry (Principal investigator)
Phosphines, Phosphine oxides, Wittig reactions, Appel reactions, Reduction reactions
Physical Sciences (P)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
2 To examine the scope and mechanism of the phosphine oxide-catalyzed conjugate reduction of conjugated polyunsaturated ketones. 3 To examine the application of phosphine-initiated reaction sequences involving Wittig reactions followed by reduction reactions in natural product synthesis. 4 To study the possibility of reaction sequences involving Appel reactions followed by reductive alkylation. 5 To examine the utility of phosphine-initiated reaction sequences involving aza-Wittig and related reactions for the synthesis of amines and amine derivatives.