Phosphine- and Phosphine Oxide-Initiated Reaction Sequences


Grant Data
Project Title
Phosphine- and Phosphine Oxide-Initiated Reaction Sequences
Principal Investigator
Dr Toy, Patrick Henry   (Principal investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
706972
Conference Title
Presentation Title
Keywords
Phosphines, Phosphine oxides, Wittig reactions, Appel reactions, Reduction reactions
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17305915
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To examine the scope and mechanism of the phosphine oxide-catalyzed conjugate reduction of conjugated polyunsaturated ketones. 3 To examine the application of phosphine-initiated reaction sequences involving Wittig reactions followed by reduction reactions in natural product synthesis. 4 To study the possibility of reaction sequences involving Appel reactions followed by reductive alkylation. 5 To examine the utility of phosphine-initiated reaction sequences involving aza-Wittig and related reactions for the synthesis of amines and amine derivatives.