Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery


Grant Data
Project Title
Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery
Principal Investigator
Dr Kwok, Philip Chi Lip   (Principal investigator)
Co-Investigator(s)
Dr Lam Jenny Ka Wing   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
501255
Conference Title
Presentation Title
Keywords
Porous carriers, Nanoparticles, Aerosol, Controllable particle density, Respiratory drug delivery
Discipline
Chemical Engineering
Panel
Physical Sciences (P)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17302815
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To produce blank porous carriers by spray drying solutions containing the carrier former and pore-forming agent and characterise their physicochemical properties and aerosol performance. 3 To test the effect of nanoparticle loading on the physicochemical properties, aerosol performance, and dissolution behaviour of spray dried porous carriers. 4 To measure the rate of drug transport across an airway epithelial cell model after dispersing the optimal spray freeze dried and spray dried nanoparticle-loaded carriers.