Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery
Grant Data
Project Title
Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery
Principal Investigator
Dr Lam, Jenny Ka Wing
(Principal Investigator (PI))
Co-Investigator(s)
Dr Kwok Philip Chi Lip
(Co-Investigator)
Duration
42
Start Date
2016-01-01
Amount
501255
Conference Title
Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery
Presentation Title
Keywords
Aerosol, Controllable particle density, Nanoparticles, Porous carriers, Respiratory drug delivery
Discipline
Chemical Engineering
Panel
Physical Sciences (P)
HKU Project Code
17302815
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To test the effect of nanoparticle loading on the physicochemical properties, aerosol performance, and dissolution behaviour of spray freeze dried large porous carriers. 2 To produce blank porous carriers by spray drying solutions containing the carrier former and pore-forming agent and characterise their physicochemical properties and aerosol performance. 3 To test the effect of nanoparticle loading on the physicochemical properties, aerosol performance, and dissolution behaviour of spray dried porous carriers. 4 To measure the rate of drug transport across an airway epithelial cell model after dispersing the optimal spray freeze dried and spray dried nanoparticle-loaded carriers.