Directing the ion transport activity and death of living cells via imposed volume changes


Grant Data
Project Title
Directing the ion transport activity and death of living cells via imposed volume changes
Principal Investigator
Dr Lin, Yuan   (Principal investigator)
Co-Investigator(s)
Mr Yip Tak Chun Timothy   (Co-Investigator)
Professor Gao Hua Jian   (Co-Investigator)
Dr Ngan Roger Kai Cheong   (Co-Investigator)
Duration
36
Start Date
2015-12-01
Completion Date
2018-11-30
Amount
495728
Conference Title
Presentation Title
Keywords
Cell Mechanics, Cell Volume, Cell Death, Ion Transport, Cancer Cells
Discipline
Mechanics and Dynamics
Panel
Engineering (E)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17211215
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
1) To develop methods allowing us to control the cell volume in a precise and programmable manner; 2) To carefully examine the transmembrane ion transport in various cells under imposed volume regulation; 3) To systematically explore the possibility of using imposed volume changes to selectively kill different cancer cells; 4) To model the size evolution of cells induced by different volume-changing cues.