Directing the ion transport activity and death of living cells via imposed volume changes
Grant Data
Project Title
Directing the ion transport activity and death of living cells via imposed volume changes
Principal Investigator
Dr Lin, Yuan
(Principal Investigator (PI))
Co-Investigator(s)
Professor Gao Hua Jian
(Co-Investigator)
Dr Ngan Roger Kai Cheong
(Co-Investigator)
Mr Yip Tak Chun Timothy
(Co-Investigator)
Duration
36
Start Date
2015-12-01
Amount
495728
Conference Title
Directing the ion transport activity and death of living cells via imposed volume changes
Presentation Title
Keywords
Cancer Cells, Cell Death, Cell Mechanics, Cell Volume, Ion Transport
Discipline
Mechanics and Dynamics
Panel
Engineering (E)
HKU Project Code
17211215
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1) To develop methods allowing us to control the cell volume in a precise and programmable manner; 2) To carefully examine the transmembrane ion transport in various cells under imposed volume regulation; 3) To systematically explore the possibility of using imposed volume changes to selectively kill different cancer cells; 4) To model the size evolution of cells induced by different volume-changing cues.