Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department ??a multicentre randomised clinical trial.
Dr Chan, Esther Wai Yin (Principal investigator)
Dr Lui Chun Tat (Co-Investigator)
Dr Chan Kin Ling (Co-Investigator)
Dr Knott Jonathan Charles (Co-Investigator)
Professor Taylor David (Co-Investigator)
Dr Kong David CM (Co-Investigator)
Dr Tsui Matthew Sik Hon (Co-Investigator)
Professor Wong Ian Chi Kei (Co-Investigator)
Dr Leung Ling Pong (Co-Investigator)
Agitation, Sedation, Olanzapine, Haloperidol, Diazepam
Biology and Medicine (M)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
1 To determine the safety and efficacy of oral olanzapine oro-dispersible tablets (wafer), in comparison with oral conventional drugs (haloperidol or diazepam) in a three-arm comparison for the sedation of acutely agitated patients in AEDs. Specifically, to determine if administration of oral olanzapine: (a)is more effective than oral haloperidol or oral diazepam alone; (b)is safer than comparison arms with respect to adverse events; (c)decreases the amount of redosing required using the same or alternate drugs; or parenteral sedation.