Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department ??a multicentre randomised clinical trial.


Grant Data
Project Title
Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department ??a multicentre randomised clinical trial.
Principal Investigator
Dr Chan, Esther Wai Yin   (Principal investigator)
Co-Investigator(s)
Dr Lui Chun Tat   (Co-Investigator)
Dr Chan Kin Ling   (Co-Investigator)
Dr Knott Jonathan Charles   (Co-Investigator)
Professor Taylor David   (Co-Investigator)
Dr Kong David CM   (Co-Investigator)
Dr Tsui Matthew Sik Hon   (Co-Investigator)
Professor Wong Ian Chi Kei   (Co-Investigator)
Dr Leung Ling Pong   (Co-Investigator)
Duration
36
Start Date
2016-06-30
Completion Date
2019-06-29
Amount
1072525
Conference Title
Presentation Title
Keywords
Agitation, Sedation, Olanzapine, Haloperidol, Diazepam
Discipline
Clinical Trials
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17111615
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
1 To determine the safety and efficacy of oral olanzapine oro-dispersible tablets (wafer), in comparison with oral conventional drugs (haloperidol or diazepam) in a three-arm comparison for the sedation of acutely agitated patients in AEDs. Specifically, to determine if administration of oral olanzapine: (a)is more effective than oral haloperidol or oral diazepam alone; (b)is safer than comparison arms with respect to adverse events; (c)decreases the amount of redosing required using the same or alternate drugs; or parenteral sedation.