Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial.

Dr Chan, Esther Wai Yin   (Principal Investigator (PI))

Dr Lui Chun Tat   (Co-Investigator)

Dr Tsui Matthew Sik Hon   (Co-Investigator)

Professor Wong Ian Chi Kei   (Co-Investigator)

Dr Kong David CM   (Co-Investigator)

Dr Knott Jonathan Charles   (Co-Investigator)

Professor Taylor David   (Co-Investigator)

Dr Chan Kin Ling   (Co-Investigator)

Dr Leung Ling Pong   (Co-Investigator)

36

2016-06-30

1072525

Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial.

Agitation, Diazepam, Haloperidol, Olanzapine, Sedation

Clinical Trials

Biology and Medicine (M)

17111615

General Research Fund (GRF)

2015

Completed

1 To determine the safety and efficacy of oral olanzapine oro-dispersible tablets (wafer), in comparison with oral conventional drugs (haloperidol or diazepam) in a three-arm comparison for the sedation of acutely agitated patients in AEDs. Specifically, to determine if administration of oral olanzapine: (a)is more effective than oral haloperidol or oral diazepam alone; (b)is safer than comparison arms with respect to adverse events; (c)decreases the amount of redosing required using the same or alternate drugs; or parenteral sedation.