Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial.
Dr Chan, Esther Wai Yin (Principal investigator)
Dr Lui Chun Tat (Co-Investigator)
Dr Chan Kin Ling (Co-Investigator)
Dr Knott Jonathan Charles (Co-Investigator)
Professor Taylor David (Co-Investigator)
Dr Kong David CM (Co-Investigator)
Dr Tsui Matthew Sik Hon (Co-Investigator)
Professor Wong Ian Chi Kei (Co-Investigator)
Dr Leung Ling Pong (Co-Investigator)
Agitation, Sedation, Olanzapine, Haloperidol, Diazepam
Biology and Medicine (M)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
1 To determine the safety and efficacy of oral olanzapine oro-dispersible tablets (wafer), in comparison with oral conventional drugs (haloperidol or diazepam) in a three-arm comparison for the sedation of acutely agitated patients in AEDs. Specifically, to determine if administration of oral olanzapine: (a)is more effective than oral haloperidol or oral diazepam alone; (b)is safer than comparison arms with respect to adverse events; (c)decreases the amount of redosing required using the same or alternate drugs; or parenteral sedation.