The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Grant Data
Project Title
The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Principal Investigator
Professor Sham, Mai Har
(Principal Investigator (PI))
Co-Investigator(s)
Professor Lendahl Urban
(Co-Investigator)
Duration
36
Start Date
2016-01-01
Amount
1180783
Conference Title
The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Presentation Title
Keywords
branchial arch, Eya1, NICD, Notch signaling, phosphatase
Discipline
Developmental Biology
Panel
Biology and Medicine (M)
HKU Project Code
17113415
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 Investigation of the role of Eya1 in the ectodermal epithelium during branchial arch segmentation. The requirement of Eya1 in maintaining the branchial epithelial signaling centres for controlling branchial arch segmentation will be investigated. 2 Investigation of the molecular interactions between Eya1 and Notch receptor intracellular domain NICD, and the role of Eya1 phosphatase in modulating the phosphorylation of NICD and Notch signaling activity. 3 Investigation of the cooperation between Notch signaling and Eya1 in branchial arch development. By gain-of-function approach to over-expression of NICD, and loss-of-function approach to knockout Rbpj, the requirement of Notch signaling in branchial arch segmentation will be investigated.