The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development


Grant Data
Project Title
The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Principal Investigator
Professor Sham, Mai Har   (Principal investigator)
Co-Investigator(s)
Professor Lendahl Urban   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1180783
Conference Title
Presentation Title
Keywords
Eya1, NICD, branchial arch, phosphatase, Notch signaling
Discipline
Developmental Biology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17113415
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 Investigation of the molecular interactions between Eya1 and Notch receptor intracellular domain NICD, and the role of Eya1 phosphatase in modulating the phosphorylation of NICD and Notch signaling activity. 3 Investigation of the cooperation between Notch signaling and Eya1 in branchial arch development. By gain-of-function approach to over-expression of NICD, and loss-of-function approach to knockout Rbpj, the requirement of Notch signaling in branchial arch segmentation will be investigated.