Genetic interaction between SUFU, GLI2 and βTrCP in medulloblastoma tumorigenesis

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Grant Data
Project Title
Genetic interaction between SUFU, GLI2 and βTrCP in medulloblastoma tumorigenesis
Principal Investigator
Professor Ngan, Elly Sau Wai   (Principal Investigator (PI))
Co-Investigator(s)
Professor Hui Chi-Chung   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Amount
969066
Conference Title
Genetic interaction between SUFU, GLI2 and βTrCP in medulloblastoma tumorigenesis
Presentation Title
Keywords
BTRC, Gli, Hedgehog, Medulloblastoma, Sufu
Discipline
Growth and Development
Panel
Biology and Medicine (M)
HKU Project Code
17109215
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To decipher how loss of Sufu suppresses SHH-MB tumorigenesis using conditional Sufu;PtcKO mice 2 To delineate the molecular mechanism underlying the oncogenic functions of Sufu in MB tumorigenesis to identify potential new therapeutic targets