Neurochemical basis of the change in attention control and memory encoding in normal aging
Dr Mak, Henry Ka Fung (Principal investigator)
normal aging, proton MR spectroscopy, task-based BOLD-fMRI, glutamate, cognitive processes
Biology and Medicine (M)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
2 To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-?4 positive) compared to those with low risk. Impact: if metabolic and functional changes are observed in pre-symptomatic subjects with high risk of developing AD, this technique may become a useful tool for non-invasive early diagnosis. 3 To investigate the change in Glu:Gln ratios with age in the ACC and bilateral hippocampi. Impact: close regulation of the breakdown from Glu into Gln could be a protective function against excitotoxicity from excess Glu in the synaptic cleft. Damage to this regulatory mechanism could lead to neuronal death and pathogenesis.