Neurochemical basis of the change in attention control and memory encoding in normal aging


Grant Data
Project Title
Neurochemical basis of the change in attention control and memory encoding in normal aging
Principal Investigator
Dr Mak, Henry Ka Fung   (Principal investigator)
Co-Investigator(s)
Professor Chu Leung Wing   (Co-Investigator)
Dr Song You-qiang   (Co-Investigator)
Dr Shea Yat Fung   (Co-Investigator)
Professor Yau Kelvin Kai wing   (Co-Investigator)
Dr Wong Wai Ho Savio   (Co-Investigator)
Dr Kwan Shiu Kwong Joseph   (Co-Investigator)
Dr Chiu Pui Wai   (Co-Investigator)
Duration
24
Start Date
2015-12-01
Completion Date
2017-11-30
Amount
417221
Conference Title
Presentation Title
Keywords
normal aging, proton MR spectroscopy, task-based BOLD-fMRI, glutamate, cognitive processes
Discipline
Imaging
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17108315
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-?4 positive) compared to those with low risk. Impact: if metabolic and functional changes are observed in pre-symptomatic subjects with high risk of developing AD, this technique may become a useful tool for non-invasive early diagnosis. 3 To investigate the change in Glu:Gln ratios with age in the ACC and bilateral hippocampi. Impact: close regulation of the breakdown from Glu into Gln could be a protective function against excitotoxicity from excess Glu in the synaptic cleft. Damage to this regulatory mechanism could lead to neuronal death and pathogenesis.