Phenolic-type Reactive Carbonyl Scavengers as Inhibitors against the Formation of Advanced Glycation End Products (AGEs) and AGEs-induced Endothelial Dysfunction, Cell Apoptosis and Inflammation
Grant Data
Project Title
Phenolic-type Reactive Carbonyl Scavengers as Inhibitors against the Formation of Advanced Glycation End Products (AGEs) and AGEs-induced Endothelial Dysfunction, Cell Apoptosis and Inflammation
Principal Investigator
Dr Wang, Mingfu
(Principal Investigator (PI))
Co-Investigator(s)
Professor Huang Yu
(Co-Investigator)
Duration
24
Start Date
2015-10-01
Amount
733535
Conference Title
Phenolic-type Reactive Carbonyl Scavengers as Inhibitors against the Formation of Advanced Glycation End Products (AGEs) and AGEs-induced Endothelial Dysfunction, Cell Apoptosis and Inflammation
Presentation Title
Keywords
Advanced glycation endproducts, Diabetes, methylglyoxal, Phenolics, Reactive carbonyl species
Discipline
Food Science
Panel
Biology and Medicine (M)
HKU Project Code
17111715
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 Establishing human umbilical vein endothelial cells (HUVECs) as the cell model to evaluate the methylglyoxal-scavenging capacity of some selected phenolics and phenolic-enriched extracts; 2 Investigating the protective effects of some selected phenolics/extracts on the direct formation of AGEs, induced oxidative stress, and endothelial dysfunction in HUVECs; 3 Investigating the inhibitory effect of selected phenolics on AGEs-induced endothelial cell apoptosis and inflammation and the underlying mechanisms; 4 Investigate the protective effects of these selected phenolics/extracts against AGEs formation, oxidative stress and endothelial dysfunction in arteries from db/db mice and their direct impact on glucose homeostasis.