Phenolic-type Reactive Carbonyl Scavengers as Inhibitors against the Formation of Advanced Glycation End Products (AGEs) and AGEs-induced Endothelial Dysfunction, Cell Apoptosis and Inflammation


Grant Data
Project Title
Phenolic-type Reactive Carbonyl Scavengers as Inhibitors against the Formation of Advanced Glycation End Products (AGEs) and AGEs-induced Endothelial Dysfunction, Cell Apoptosis and Inflammation
Principal Investigator
Dr Wang, Mingfu   (Principal investigator)
Co-Investigator(s)
Professor Huang Yu   (Co-Investigator)
Duration
24
Start Date
2015-10-01
Completion Date
2017-09-30
Amount
733535
Conference Title
Presentation Title
Keywords
Phenolics, Reactive carbonyl species, Advanced glycation endproducts, methylglyoxal, Diabetes
Discipline
Food Science
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17111715
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 Investigating the protective effects of some selected phenolics/extracts on the direct formation of AGEs, induced oxidative stress, and endothelial dysfunction in HUVECs; 3 Investigating the inhibitory effect of selected phenolics on AGEs-induced endothelial cell apoptosis and inflammation and the underlying mechanisms; 4 Investigate the protective effects of these selected phenolics/extracts against AGEs formation, oxidative stress and endothelial dysfunction in arteries from db/db mice and their direct impact on glucose homeostasis.