Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Grant Data
Project Title
Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Principal Investigator
Dr Ching, Yick Pang
(Principal Investigator (PI))
Duration
48
Start Date
2016-01-01
Amount
1153232
Conference Title
Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Presentation Title
Keywords
centrosome, hepatocellular carcinoma, kinase, metastasis, oncogene
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17111015
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 i) Examining the tumorigenic activity of PLK4 in HCC cells ii) Investigating the role of PLK4 in enhancing HCC cell survival 2 i) Characterizing the phosphorylation of TAX1BP2 by PLK4 ii) Evaluating the effect of PLK4 phosphorylation on tumour suppressor activity of TAX1BP2 iii) Exploring the role of PLK4 phosphorylation of TAX1BP2 in centrosome overduplication 3 i) Investigating the role of PLK4 in enhancing HCC chemo-resistance