Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis


Grant Data
Project Title
Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Principal Investigator
Dr Ching, Yick Pang   (Principal investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1153232
Conference Title
Presentation Title
Keywords
hepatocellular carcinoma, centrosome, kinase, oncogene, metastasis
Discipline
Cancer
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17111015
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 i) Characterizing the phosphorylation of TAX1BP2 by PLK4 ii) Evaluating the effect of PLK4 phosphorylation on tumour suppressor activity of TAX1BP2 iii) Exploring the role of PLK4 phosphorylation of TAX1BP2 in centrosome overduplication 3 i) Investigating the role of PLK4 in enhancing HCC chemo-resistance