Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR


Grant Data
Project Title
Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR
Principal Investigator
Dr Chen, Jeng-Haur   (Principal investigator)
Co-Investigator(s)
Dr Li Gui-Rong   (Co-Investigator)
Professor Chan Ying Shing   (Co-Investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
1200816
Conference Title
Presentation Title
Keywords
CFTR, cystic fibrosis, bicarbonate, ion channel, intracellular pH
Discipline
Genetic Disease
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17106315
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To investigate the bicarbonate transport and impaired pHi sensitivity of ΔF508-CFTR. 3 To compare the anion transport in the epithelia expressing wild-type or ΔF508-CFTR.