The novel role of hematopoietic APPL1 in regulating adipose tissue inflammation and insulin resistance in obesity


Grant Data
Project Title
The novel role of hematopoietic APPL1 in regulating adipose tissue inflammation and insulin resistance in obesity
Principal Investigator
Dr Cheng, King Yip   (Principal investigator)
Co-Investigator(s)
Professor Xu Aimin   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1032327
Conference Title
Presentation Title
Keywords
Autophagy, Inflammation, Adipose tissue, macrophage, obesity and diabetes
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17101815
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To examine whether APPL1 prevents obesity-induced inflammation by promoting autophagy in macrophages. 3 To elucidate whether APPL1 potentiates autophagy via the Rab5-Vps34 signaling axis.