Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Grant Data
Project Title
Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Principal Investigator
Emeritus Professor Lung, Maria Li
(Principal Investigator (PI))
Duration
36
Start Date
2015-09-01
Amount
961461
Conference Title
Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Presentation Title
Keywords
Cancer-related pathways, MIPOL1, Nasopharyngeal Carcinoma, RhoB, tumor suppressor gene
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17101715
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 Examine the clinical significance of MIPOL1 and its downstream signaling targets in NPC clinical samples 2 Provide mechanistic insight into MIPOL1 regulation of the cancer-related defective signaling pathways in NPC cells and functionally validate its role utilizing different in vivo and in vitro functional assays. 3 Identify MIPOL1 DNA binding target(s) and investigate the abilities of MIPOL1 in regulating their gene expression in NPC