Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma


Grant Data
Project Title
Functional and mechanistic characterizations of a Candidate Tumor Suppressor Gene, Mirror Image Polydactyly 1, in Nasopharyngeal Carcinoma
Principal Investigator
Professor Lung, Maria Li   (Principal investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
961461
Conference Title
Presentation Title
Keywords
Nasopharyngeal Carcinoma, MIPOL1, tumor suppressor gene, RhoB, Cancer-related pathways
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17101715
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 Provide mechanistic insight into MIPOL1 regulation of the cancer-related defective signaling pathways in NPC cells and functionally validate its role utilizing different in vivo and in vitro functional assays. 3 Identify MIPOL1 DNA binding target(s) and investigate the abilities of MIPOL1 in regulating their gene expression in NPC