Molecular Mechanisms Underlying the Progressive Development of Pulmonary Arterial Hypertension in Secretin Knockout Mice


Grant Data
Project Title
Molecular Mechanisms Underlying the Progressive Development of Pulmonary Arterial Hypertension in Secretin Knockout Mice
Principal Investigator
Professor Chow, Billy Kwok Chong   (Principal investigator)
Co-Investigator(s)
Dr Law Ka Wai Helen   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1100302
Conference Title
Presentation Title
Keywords
pulmonary art. hypertension, secretin, secretin knockout, right ventricular hypertrophy, perivascular fibrosis
Discipline
Endocrinology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17127215
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To examine the molecular mechanisms for SCT in the advancement of PAH in SCT-/- mice 3 To test the potential therapeutic usage of SCT for protecting and/or reversing PAH symptoms in SCT-/- mice as well as a drug-induced PAH animal model