PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy


Grant Data
Project Title
PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy
Principal Investigator
Dr Xia, Zhengyuan   (Principal investigator)
Co-Investigator(s)
Dr Yue Jianbo   (Co-Investigator)
Professor Irwin Michael Garnet   (Co-Investigator)
Dr Wang John Junwen   (Co-Investigator)
Professor Xu Aimin   (Co-Investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
860359
Conference Title
Presentation Title
Keywords
Ischemia, Diabetes, Caveolin-3, Autophagy
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
Sponsor
RGC Early Career Scheme (ECS)
HKU Project Code
17123915
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To determine the role of hyperglycemia-induced PKCs2 over-activation in diabetic myocardial IRI and its relationship/interplay with Cav-3, exploring their impacts on cardiomyocyte autophagy 3 To determine the role of Cav-3 in diabetic myocardial IRI and its impact on PKCs2 inhibition mediated attenuation of myocardial IRI in diabetes