The role of repressor and activator protein1 (Rap1) on liver graft injury after transplantation


Grant Data
Project Title
The role of repressor and activator protein1 (Rap1) on liver graft injury after transplantation
Principal Investigator
Professor Man, Kwan   (Principal investigator)
Co-Investigator(s)
Professor Lo Chung Mau   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1170113
Conference Title
Presentation Title
Keywords
Liver graft injury, Inflammatory response, gene knockout mice
Discipline
Transplantation
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17115515
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 2.To elucidate the direct role of Rap1 promoting hepatic ischemia-reperfusion injury of small liver remnant in a Rap1 gene knockout mice model. 3 3.To explore the regulating mechanism of Rap1 on inflammatory signaling in neutrophils and macrophages using primary cells from Rap1 gene knockout mice.