Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus


Grant Data
Project Title
Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus
Principal Investigator
Professor Tu, Wenwei   (Principal investigator)
Co-Investigator(s)
Duration
24
Start Date
2016-01-01
Completion Date
2017-12-31
Amount
1022409
Conference Title
Presentation Title
Keywords
gammadelta-T cells, influenza virus, CD137, innate immunity
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17115015
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To determine whether CD137 signal can stimulate the activation and expansion of human gammadelta-T cells in vitro. 3 To determine whether CD137 signal can increase the antiviral activity of human gammadelta-T cells against influenza virus in vitro. 4 To determine whether CD137 signal can stimulate the activation and expansion of human gammadelta-T cells in vivo. 5 To determine whether CD137 signal can enhance antiviral activity of human gammadelta-T cells against influenza virus in vivo.