Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Grant Data
Project Title
Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Principal Investigator
Dr Yu, Cheng-Han
(Principal Investigator (PI))
Duration
36
Start Date
2015-09-01
Amount
900942
Conference Title
Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Presentation Title
Keywords
4)P2 and synaptojanin2, Cancer cell invasion, Invadosome formation, Optogenetics, PI(3, PI3K activation
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
27110615
Grant Type
Early Career Scheme (ECS)
Funding Year
2015
Status
Completed
Objectives
1 To define the composition and sequential production of phosphatidylinositol species at the invadosome. 2 To define the functional role of phosphoinositide phosphatase synaptojanin2 and PI(3,4)P2 lipid at the invadosome. 3 To apply optogenetical approach to suppress PI3K activation and invadosome formation.