Investigating phosphatidylinositol lipid signaling at the cancer invadosome


Grant Data
Project Title
Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Principal Investigator
Dr Yu, Cheng-Han   (Principal investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
900942
Conference Title
Presentation Title
Keywords
Invadosome formation, Cancer cell invasion, PI3K activation, PI(3, 4)P2 and synaptojanin2, Optogenetics
Discipline
Cancer
Panel
Biology and Medicine (M)
Sponsor
RGC Early Career Scheme (ECS)
HKU Project Code
27110615
Grant Type
Early Career Scheme (ECS)
Funding Year
2015/2016
Status
On-going
Objectives
2 To define the functional role of phosphoinositide phosphatase synaptojanin2 and PI(3,4)P2 lipid at the invadosome. 3 To apply optogenetical approach to suppress PI3K activation and invadosome formation.