Dataset

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Title of Dataset
Data from: Characterizing Thalamocortical Disturbances in Cervical Spondylotic Myelopathy: Revealed by Functional Connectivity under Two Slow Frequency Bands
Author of Dataset
Zhou, Fuqing1
Wu, Lin2
Liu, Xiaojia3
Gong, Honghan2
Contact
Hu, Yong3
Date of Dataset Creation
2015-06-08
Description
Background and Purpose Recent advanced MRI studies on cervical spondylotic myelopathy (CSM) revealed alterations of sensorimotor cortex, but the disturbances of large-scale thalamocortical systems remains elusive. The purpose of this study was to characterizing the CSM-related thalamocortical disturbances, which were associated with spinal cord structural injury, and clinical measures. Methods A total of 17 patients with degenerative CSM and well-matched control subjects participated. Thalamocortical disturbances were quantified using thalamus seed-based functional connectivity in two distinct low frequencies bands (slow-5 and slow-4), with different neural manifestations. The clinical measures were evaluated by Japanese Orthopaedic Association (JOA) score system and Neck Disability Index (NDI) questionnaires. Results Decreased functional connectivity was found in the thalamo-motor, -somatosensory, and -temporal circuits in the slow-5 band, indicating impairment of thalamo-cortical circuit degeneration or axon/synaptic impairment. By contrast, increased functional connectivity between thalami and the bilateral primary motor (M1), primary and secondary somatosensory (S1/S2), premotor cortex (PMC), and right temporal cortex was detected in the slow-4 band, and were associated with higher fractional anisotropy values in the cervical cord, corresponding to mild spinal cord structural injury. Conclusions These thalamocortical disturbances revealed by two slow frequency bands inform basic understanding and vital clues about the sensorimotor dysfunction in CSM. Further work is needed to evaluate its contribution in central functional reorganization during spinal cord degeneration.
Citation
Zhou, F, Wu, L, Liu, X, Gong, H, Luk, KDK, Hu, Y. (2015). Data from: Characterizing Thalamocortical Disturbances in Cervical Spondylotic Myelopathy: Revealed by Functional Connectivity under Two Slow Frequency Bands. [Data File]. All relevant data are within the paper, supporting information, and supplementary data attached to the publication. Click on “Linked Publications” to access the publication and access supporting information on figshare at https://figshare.com/articles/_Characterizing_Thalamocortical_Disturbances_in_Cervical_Spondylotic_Myelopathy_Revealed_by_Functional_Connectivity_under_Two_Slow_Frequency_Bands_/1440950
Subject (RGC Codes)
M2 — Medicine, Dentistry & Health — 醫學, 牙科學及保健
  • 1224 — Orthopaedics/Traumatology — 骨科/創傷學
Subject (ANZSRC)
11 — MEDICAL AND HEALTH SCIENCES — 醫學與衛生科學
  • 1103 — CLINICAL SCIENCES — 臨床科學
    • 110314 — Orthopaedics — 整形學
Keyword
injury.ConclusionsThese thalamocortical disturbances
joa
thalamocortical systems
anisotropy values
Thalamocortical disturbances
MRI studies
functional connectivity
csm
circuit
Cervical spondylotic myelopathy
somatosensory
sensorimotor dysfunction
pmc
ndi
neck disability index
sensorimotor cortex
17 patients
score system
frequency bands
Japanese Orthopaedic Association
impairment
connectivity
cord degeneration
spondylotic myelopathy
frequencies bands
Affiliations
  1. NanChang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Jiangxi, Peoples R China ; Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China
  2. NanChang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Jiangxi, Peoples R China
  3. Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China